Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) andin vitro toxicology testing methods associated with toxicological analysis and preclinical drug development.
As in the first edition, the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing.
Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters.
Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications, the concepts of standardization and validation ofin vitro techniques (especially large, organized validation efforts currently supported by US and EU regulatory agencies), and the theories supporting the development ofin vitro methodologies.
This second edition is a must-read for undergraduate and graduate toxicology students. Industrial and academic research centers will also find the text useful for establishing a toxicology testing laboratory.
A majority of the Fortune 500 Companies implement some practice of workplace drug testing in their company policies. This practice was first initiated by President Ronald Reagan when he ordered federal agencies to drug test federal employees involved in sensitive positions as well as positions involving public safety.
As a practicing toxicologist, Dr. Amitava Dasgupta is involved with the pre-employment drug testing at his own hospital and aptly shares his expertise in Beating Drug Tests and Defending Positive Results: A Toxicologist s Perspective, which covers all major issues concerning how people try to beat drug tests and defend positive test results. In each chapter, extensive references are cited so that readers can access more information on a particular topic that may interest them. The book will undoubtedly prove helpful to toxicologists, medical technologists, pathologists, human resources professionals and anyone interested in workplace drug testing."
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Software testing is rapidly evolving as a critical sub-discipline of software engineering. The industry needs professionals educated in the modern methods and tools of software testing and quality assurance. Based on the needs of software professionals, "Practical Software Testing" takes a unique approach to teaching readers how to effectively plan for testing, design test cases, test at multiple levels, organize a testing team, and optimize use of testing tools. It introduces testing concepts that are managerial-, technical-, and process-oriented, using the Testing Maturity Model (TMM) as a framework. Features: *includes a sample test plan, comprehensive exercises, and definitions for software testing and quality *introduces both technical and managerial aspects of testing in a clear and precise style, for integrated learning *balanced perspective and comprehensive view of all testing aspects *uses the TMM framework to introduce testing in a systematic, evolutionary way, and describes industrial TMM applications *covers testing topics with either procedurally based or object-oriented programming code With its accessible, practical, and well-focused framework, this new resource provides an integrated presentation of software-testing processes and practices. Professionals and practitioners in software testing, software quality assurance, or software validation and verification will benefit greatly from using this essential resource.
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