A majority of the Fortune 500 Companies implement some practice of workplace drug testing in their company policies. This practice was first initiated by President Ronald Reagan when he ordered federal agencies to drug test federal employees involved in sensitive positions as well as positions involving public safety.
As a practicing toxicologist, Dr. Amitava Dasgupta is involved with the pre-employment drug testing at his own hospital and aptly shares his expertise in Beating Drug Tests and Defending Positive Results: A Toxicologist s Perspective, which covers all major issues concerning how people try to beat drug tests and defend positive test results. In each chapter, extensive references are cited so that readers can access more information on a particular topic that may interest them. The book will undoubtedly prove helpful to toxicologists, medical technologists, pathologists, human resources professionals and anyone interested in workplace drug testing."
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Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) andin vitro toxicology testing methods associated with toxicological analysis and preclinical drug development.
As in the first edition, the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing.
Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters.
Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications, the concepts of standardization and validation ofin vitro techniques (especially large, organized validation efforts currently supported by US and EU regulatory agencies), and the theories supporting the development ofin vitro methodologies.
This second edition is a must-read for undergraduate and graduate toxicology students. Industrial and academic research centers will also find the text useful for establishing a toxicology testing laboratory.
Volume 28 in the series of Side Effects of Drugs Annuals (http://www.elsevier.com/locate/series/seda) continues to serve its primary goal: to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions. An international team of specialists has reviewed new data and trends by selecting from the year's writing all that is truly new and informative, by critically interpreting it, and by pointing to whatever is unproven or misleading. The use of the book is enhanced by separate indexes, allowing the reader to access the text via drug name, adverse effect, or drug interaction.
This book explains the key steps in planning and executing diagnostic test accuracy studies in dementia, with clear explanations of difficulties and pitfalls and with jargon clearly explained. The emphasis is on pragmatic diagnostic test accuracy studies which can be integrated into day-to-day clinical practice. The book is based on the author's experience over more than 10 years, which has resulted in the publication of many diagnostic test accuracy studies.
The text is structured as for a research publication on a diagnostic test accuracy study (Introduction, Methods, Results, Discussion), with a final chapter on Future Prospects. Each of the chapters is devoted to a practical and structured overview of each of these steps in performing and writing up such a study.
Diagnostic Test Accuracy Studies in Dementia: A Pragmatic Approach is aimed at any clinician with an interest in dementia disorders: old age psychiatrists, geriatricians, neurologists, neuropsychologists and primary care physicians, as well as other professions allied to medicine. The book is also of interest to any clinician/researcher with an interest in diagnostic test accuracy studies.
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