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A majority of the Fortune 500 Companies implement some practice of workplace drug testing in their company policies. This practice was first initiated by President Ronald Reagan when he ordered federal agencies to drug test federal employees involved in sensitive positions as well as positions involving public safety.
As a practicing toxicologist, Dr. Amitava Dasgupta is involved with the pre-employment drug testing at his own hospital and aptly shares his expertise in Beating Drug Tests and Defending Positive Results: A Toxicologist s Perspective, which covers all major issues concerning how people try to beat drug tests and defend positive test results. In each chapter, extensive references are cited so that readers can access more information on a particular topic that may interest them. The book will undoubtedly prove helpful to toxicologists, medical technologists, pathologists, human resources professionals and anyone interested in workplace drug testing."
Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) andin vitro toxicology testing methods associated with toxicological analysis and preclinical drug development.
As in the first edition, the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing.
Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters.
Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications, the concepts of standardization and validation ofin vitro techniques (especially large, organized validation efforts currently supported by US and EU regulatory agencies), and the theories supporting the development ofin vitro methodologies.
This second edition is a must-read for undergraduate and graduate toxicology students. Industrial and academic research centers will also find the text useful for establishing a toxicology testing laboratory.
The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
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